研究者総覧 Researchers Information 検索 English 研究者総覧 所属別一覧 研究分野別一覧 詳細検索 使い方 お問い合わせ 松﨑 仁美(マツザキ ヒトミ) 所属 生命環境系 職名 助教 研究課題ゲノム刷り込みの階層性制御におけるシス配列トポロジーの役割2023 -- 2025松_ 仁美日本学術振興会/基盤研究(C)4,680,000円哺乳類の正常発生を支える非対称性DNAメチル化維持機構の解明2020 -- 2021松﨑 仁美日本学術振興会/新学術領域研究（研究領域提案型）8,320,000円哺乳類の世代間エピジェネティックマーク変換機構の解明2020 -- 2022松﨑 仁美日本学術振興会/基盤研究(C)4,420,000円受精後刷り込みメチル化を誘導する生殖細胞エピゲノム情報の解明2017 -- 2019松﨑 仁美日本学術振興会/若手研究(A)16,770,000円マウスゲノム刷り込み遺伝子座におけるエピジェネティック修飾制御の分子メカニズム2014 -- 2016松﨑　仁美日本学術振興会/若手研究(B)4,030,000円 取得学位博士（学術）筑波大学 所属学協会2002-08 -- (現在)日本分子生物学会2003 -- (現在)日本生化学会2007-06 -- (現在)日本エピジェネティクス研究会 論文Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic miceMatsuzaki Hitomi; Takahashi Takuya; Kuramochi Daichi; ...NUCLEIC ACIDS RESEARCH/51(14)/pp.7236-7253, 2023-08The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization periodMatsuzaki Hitomi; Sugihara Shokichi; Tanimoto KeijiEpigenetics & Chromatin/16(1)/p.7, 2023-02-17PubMedOrientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanismsMatsuzaki Hitomi; Miyajima Yu; Fukamizu Akiyoshi; Tani...Communications biology/4(1)/p.1410, 2021-04PubMedTransient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation periodHirakawa Katsuhiko; Matsuzaki Hitomi; Tanimoto KeijiHuman molecular genetics/29(22)/pp.3646-3661, 2021-01PubMedRecapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locusMatsuzaki Hitomi; Kuramochi Daichi; Okamura Eiichi; Hi...Epigenetics & chromatin/13(1), 2020-01PubMedTransvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouseTanimoto Keiji; Matsuzaki Hitomi; Okamura Eiichi; Ushi...PLoS ONE/14(2)/p.e0203099, 2019-04PubMed Tsukuba RepositorySynthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic miceMatsuzaki Hitomi; Okamura Eiichi; Kuramochi Daichi; Us...Epigenetics & Chromatin/11(1)/p.36, 2018-06PubMed Tsukuba RepositoryHomeostatic response of mouse renin gene transcription in a hypertensive environment is mediated by a novel 5' enhancerUshiki Aki; Matsuzaki Hitomi; Fukamizu Akiyoshi; Tanim...Molecular and Cellular Biology/38(7)/p. e00566-17, 2018-01PubMedLong-Range Control of Renin Gene Expression in Tsukuba Hypertensive MiceUshiki Aki; Matsuzaki Hitomi; Ishida Junji; Fukamizu ...PLOS ONE/11(11), 2016-11PubMed Tsukuba RepositoryDe novo DNA methylation through the 5 '-segment of the H19 ICR maintains its imprint during early embryogenesisMatsuzaki Hitomi; Okamura Eiichi; Takahashi Takuya; Us...DEVELOPMENT/142(22)/pp.3833-3844, 2015-11PubMedA mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant miceTanimoto Keiji; Kanafusa Sumiyo; Ushiki Aki; Matsuzaki Hitom...JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION/34(5)/pp.401-409, 2014-10Sox-Oct motifs contribute to maintenance of the unmethylated H19 ICR in YAC transgenic mice.Sakaguchi R; Okamura E; Matsuzaki H; Fukamizu A; Tanimoto KHUMAN MOLECULAR GENETICS/22(22)/pp.4627-4637, 2013-11PubMedThe Chicken HS4 Insulator Element Does Not Protect the H19 ICR from Differential DNA Methylation in Yeast Artificial Chromosome Transgenic MouseEiichi Okamura; Hitomi Matsuzaki ; Fukamizu Akiyoshi; Keiji ...PLoS One./8(9), 2013-09PubMed Tsukuba RepositoryThe H19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice.Okamura Eiichi; Matsuzaki Hitomi; Sakaguchi Ryuuta; Takahash...MOLECULAR AND CELLULAR BIOLOGY/33(4)/pp.858-871, 2013-02PubMedSequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic miceTakahashi Takuya; Matsuzaki Hitomi; Tomizawa Shin-ichi; O...GENE/508(1)/pp.26-34, 2012-10PubMedDNase I Hypersensitivity and epsilon-Globin Transcriptional Enhancement Are Separable in Locus Control Region (LCR) HS1 Mutant Human beta-Globin YAC Transgenic MiceShimotsuma Motoshi; Okamura Eiichi; Matsuzaki Hitomi; Fuk...JOURNAL OF BIOLOGICAL CHEMISTRY/285(19)/pp.14495-14503, 2010-05PubMedCTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICRMatsuzaki Hitomi; Okamura Eiichi; Fukamizu Akiyoshi; Tani...HUMAN MOLECULAR GENETICS/19(7)/pp.1190-1198, 2010-04PubMedAll of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic miceOkamura Eiichi; Matsuzaki Hitomi; Campbell Andrew D.; En...FASEB JOURNAL/23(12)/pp.4335-4343, 2009-12PubMedA Randomly Integrated Transgenic H19 Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ CellsMatsuzaki Hitomi; Okamura Eiichi; Shimotsuma Motoshi; Fukami...MOLECULAR AND CELLULAR BIOLOGY/29(17)/pp.4595-4603, 2009-09Linear distance from the locus control region determines epsilon-globin transcriptional activityShimotsuma Motoshi; Matsuzaki Hitomi; Tanabe Osamu; Campb...MOLECULAR AND CELLULAR BIOLOGY/27(16)/pp.5664-5672, 2007-08PubMedMitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1Asada Sachie; Daitoku Hiroaki; Matsuzaki Hitomi; Saito T...CELLULAR SIGNALLING/19(3)/pp.519-527, 2007-03PubMedAcetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylationMatsuzaki H; Daitoku H; Hatta M; Aoyama H; Yoshimochi K; ...PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/102(32)/pp.11278-11283, 2005-08PubMedGenomic imprinting recapitulated in the human beta-globin locusTanimoto K; Shimotsuma M; Matsuzaki H; Omori A; Bungert ...PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/102(29)/pp.10250-10255, 2005-07PubMedSilent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activityDaitoku H; Hatta M; Matsuzaki H; Aratani S; Ohshima T; Mi...PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/101(27)/pp.10042-10047, 2004-07PubMedRegulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivoIshida J; Hashimoto T; Hashimoto Y; Nishiwaki S; Iguchi ...JOURNAL OF BIOLOGICAL CHEMISTRY/279(25)/pp.26274-26279, 2004-06PubMedさらに表示... 会議発表等マウスH19-ICR刷り込みDNAメチル化制御におけるBTB-Znフィンガー‧タンパク質の機能検証松﨑 仁美; 木村 美南; 森橋 美月; 谷本 啓司第46回日本分子生物学会年会/2023-12-06--2023-12-08マウスIgf2-H19遺伝子座の受精後刷り込みメチル化に関わるcis配列のin vivo検証とtrans因子の探索谷本 啓司; 松﨑 仁美第96回日本生化学会大会/2023-10-31--2023-11-02トランスジェニックマウスにおけるDlk1-Dio3遺伝子領域IG-DMRの刷り込みメチル化の検証谷本 啓司; 松﨑 仁美第95回日本生化学会大会/2022-11-09--2022-11-11マウスH19-ICRの受精後刷り込みメチル化に関わるcis制御配列と候補trans因子の探索谷本 啓司; 松﨑 仁美; 高橋 拓也; 倉持 大地; 平川 勝彦第45回日本分子生物学会年会/2022-11-30--2022-12-02H19-ICR受精後刷り込みメチル化における候補トランス因子の関与の in vivo 検証木村 美南; 松﨑 仁美; 谷本 啓司第45回日本分子生物学会年会/2022-11-30--2022-12-02Igf2/H19遺伝子座におけるゲノム刷り込み維持機構としてのH19-ICR受精後アレル特異的DNAメチル化松﨑 仁美; 谷本 啓司第45回日本分子生物学会年会/2022-11-30--2022-12-02トランスジェニックマウスにおけるラットH19-ICRのDMR形性能の検討杉原 翔吉; 松﨑 仁美; 谷本 啓司第94回日本生化学会大会/2021-11-03--2021-11-05マウスH19-ICR配列のin vivo反転によるインプリント遺伝子発現機構の解明松﨑 仁美; 宮嶋 優; 谷本 啓司第43回日本分子生物学会年会/2020-12-02--2020-12-04ヒトH19-ICR YACトランスジェニック・マウスを用いた受精後刷り込みメチル化活性の検証松﨑 仁美; 平川 勝彦; 谷本 啓司第93回日本生化学会年会/2020-9-14--2020-9-16YACトランスジェニック・マウスを用いたヒトH19-ICR刷り込みメチル化メカニズムの検証平川 勝彦; 松﨑 仁美; 谷本 啓司第42回日本分子生物学会年会/2019-12-03--2019-12-06マウスのゲノム刷り込み制御におけるH19-ICR配列反転の効果宮嶋 優; 谷本 啓司; 松﨑 仁美第42回日本分子生物学会年会/2019-12-03--2019-12-06A genetic test for transvection-like interchromosomal functional interaction at the mouse Rosa26 locusTanimoto Keiji; Matsuzaki Hitomi; Engel James Douglas第42回日本分子生物学会年会/2019-12-03--2019-12-06Reconstituted H19 ICR sequence with identified cis elements is capable of maintaining genomic imprinting in knock-in mouseMatsuzaki Hitomi; Daichi Kuramochi; katsuhiko Hirakawa; T...33rd International Mammalian Genome Conference/2019-9-25--2019-9-28Test for imprinted DNA methylation activity of the human H19-ICR in YAC transgenic mice by adopting a transgene co-placement strategyHirakawa Katsuhiko; Matsuzaki Hitomi; Tanimoto KeijiThe 15th Transgenic Technology Meeting (TT2019)/2019-04-07--2019-04-10H19-ICR 反転マウスを用いたゲノム刷り込み制御機構の解析松﨑 仁美; 宮嶋 優; 谷本 啓司第41回日本分子生物学会年会/2018-11-28--2018-11-30In vivo analysis of H19 gene transcriptional mechanism by inversion of the H19 imprinting control regionMatsuzaki Hitomi; Miyajima Yu; Tanimoto Keiji32nd International Mammalian Genome Conference/2018-11-11--2018-11-14ヒトβグロビン遺伝子座におけるH19-ICR断片挿入の効果とクロマチン立体構造解析平川 勝彦; 松﨑 仁美; 谷本 啓司第12回日本エピジェネティクス研究会年会/2018-5-24--2018-5-24H19-ICR反転によるH19遺伝子転写制御機構のin vivo解析宮嶋 優; 谷本 啓司; 松﨑 仁美第12回日本エピジェネティクス研究会年会/2018-05-24--2018-05-25Homeostatic response of renin gene transcription to hypertension is mediated by its novel 5’ enhancerTanimoto Keiji; Ushiki Aki; Matsuzaki Hitomi; Fukamizu A...Keystone Symposia (Gene Control in Development and Disease)/2018-03-23--2018-03-27Imprinted gene expression can be reconstituted by synthetic DNA fragment composed of specified cis regulatory elements from the H19 ICRMatsuzaki Hitomi; Kuramochi Daichi; Hirakawa Katsuhiko; T...Keystone Symposia (Gene Control in Development and Disease)/2018-03-23--2018-03-27レニン遺伝子の高血圧応答性を制御するエンハンサーの同定牛木亜季; 松﨑仁美; 谷本啓司; 深水昭吉2017年度遺伝研研究会/2017-12-14Enhancer-mediated regulatory mechanism of mouse renin gene transcription in hypertensive-environmentTanimoto Keiji; Ushiki Aki; Matsuzaki Hitomi; Fukamizu A...Mammalian Genetics and Genomics/2017-10-24--2017-10-27Conserved regulatory mechanisms of human and mouse renin genes expression in the hypertensive-environmentUshiki Aki; Matsuzaki Hitomi; Fukamizu Akiyoshi; Keiji T...CDB Symposium 2017 -Towards Understanding Human Development, Heredity, and Evolution-/2017-03-27--2017-03-29高血圧応答性エンハンサーによるレニン遺伝子の転写制御牛木亜季; 松﨑仁美; 谷本啓司; Fukamizu Akiyoshi第39回日本分子生物学会年会/2016-12マウスH19 ICRにおけるアリル特異的DNAメチル化制御配列の同定Matsuzaki Hitomi; 倉持 大地; 牛木 亜季; 谷本 啓司第39回日本分子生物学会年会/2016-11-30--2016-12-02さらに表示... 担当授業科目2023-10 -- 2023-12生物学序説筑波大学2023-10 -- 2024-02動物生命科学講究III筑波大学2023-04 -- 2023-08動物生命科学講究III筑波大学2023-10 -- 2024-02動物生命科学講究II筑波大学2023-04 -- 2023-08動物生命科学講究II筑波大学2023-10 -- 2024-02生命農学演習筑波大学2023-04 -- 2023-08生命農学演習筑波大学2024-01 -- 2024-02基礎生物学実験III筑波大学2023-04 -- 2023-08応用生命化学演習IS筑波大学2023-10 -- 2023-12基礎生物学実験II筑波大学さらに表示... 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